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Original Article


Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets

Micheal Abimbola Oladosu, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee Micheal Abimbola Oladosu, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee, Anthony Olalekan Akande.


Abstract
Background:
Advancements in cancer genomics have revealed that cancers developing from various organs typically share common genetic changes while also having distinctive mutational fingerprints.

Aim:
This study conducted a comparative examination of cancer-associated mutations across four main tumour types: breast, lung, colorectal, and melanoma, using integrated data from The Cancer Genome Atlas and the Catalogue of Somatic Mutations in Cancer.

Methods:
Through bioinformatics-driven mutation profiling, pathway enrichment, and immunogenomic characterization, we discovered both pan-cancer driver mutations (e.g., TP53, KRAS, PIK3CA) and tumour-specific alterations with therapeutic significance.

Results:
Shared carcinogenic pathways such as PI3K/AKT/mTOR and MAPK were implicated across cancers, whereas unique pathways such as Deoxyribonucleic Acid mismatch repair in colorectal cancer and immune evasion in melanoma highlighted tissue-specific vulnerabilities. Additionally, the study of tumour mutational burden and microsatellite instability informed immunotherapy categorisation.

Conclusion:
These findings underline the potential for both tumour-agnostic and personalised therapy methods, advancing the goals of precision oncology.

Key words: Cancer genomes; Driver mutations; Tumor heterogeneity; Therapeutic targets; Precision oncology; Immunogenomics.


 
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How to Cite this Article
Pubmed Style

Oladosu MA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Oladosu TMMA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Mukharjee T, Akande AO. Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. J Cancer Res Rev. 2026; 3(1): 20-37. doi:10.5455/JCRR.2026.v3.i1.2


Web Style

Oladosu MA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Oladosu TMMA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Mukharjee T, Akande AO. Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. https://www.jcrronline.org//?mno=263657 [Access: March 16, 2026]. doi:10.5455/JCRR.2026.v3.i1.2


AMA (American Medical Association) Style

Oladosu MA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Oladosu TMMA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Mukharjee T, Akande AO. Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. J Cancer Res Rev. 2026; 3(1): 20-37. doi:10.5455/JCRR.2026.v3.i1.2



Vancouver/ICMJE Style

Oladosu MA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Oladosu TMMA, Abah MA, Ede FO, Balogun OA, Adeniran IE, Oluwadare MI, Kokelu AN, Oladosu OA, Mukharjee T, Akande AO. Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. J Cancer Res Rev. (2026), [cited March 16, 2026]; 3(1): 20-37. doi:10.5455/JCRR.2026.v3.i1.2



Harvard Style

Oladosu, M. A., Abah, . M. A., Ede, . F. O., Balogun, . O. A., Adeniran, . I. E., Oluwadare, . M. I., Kokelu, . A. N., Oladosu, . O. A., Oladosu, . T. M. M. A., Abah, . M. A., Ede, . F. O., Balogun, . O. A., Adeniran, . I. E., Oluwadare, . M. I., Kokelu, . A. N., Oladosu, . O. A., Mukharjee, . T. & Akande, . A. O. (2026) Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. J Cancer Res Rev, 3 (1), 20-37. doi:10.5455/JCRR.2026.v3.i1.2



Turabian Style

Oladosu, Micheal Abimbola, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee Micheal Abimbola Oladosu, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee, and Anthony Olalekan Akande. 2026. Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. Journal of Cancer Research and Reviews, 3 (1), 20-37. doi:10.5455/JCRR.2026.v3.i1.2



Chicago Style

Oladosu, Micheal Abimbola, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee Micheal Abimbola Oladosu, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee, and Anthony Olalekan Akande. "Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets." Journal of Cancer Research and Reviews 3 (2026), 20-37. doi:10.5455/JCRR.2026.v3.i1.2



MLA (The Modern Language Association) Style

Oladosu, Micheal Abimbola, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee Micheal Abimbola Oladosu, Moses Adondua Abah, Franklin Ogonna Ede, Oladapo Abiola Balogun, Ifeoluwa Emmanuel Adeniran, Marvellous Inioluwa Oluwadare, Anthony Nduka Kokelu, Olaide Ayokunmi Oladosu, Tanaya Mukharjee, and Anthony Olalekan Akande. "Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets." Journal of Cancer Research and Reviews 3.1 (2026), 20-37. Print. doi:10.5455/JCRR.2026.v3.i1.2



APA (American Psychological Association) Style

Oladosu, M. A., Abah, . M. A., Ede, . F. O., Balogun, . O. A., Adeniran, . I. E., Oluwadare, . M. I., Kokelu, . A. N., Oladosu, . O. A., Oladosu, . T. M. M. A., Abah, . M. A., Ede, . F. O., Balogun, . O. A., Adeniran, . I. E., Oluwadare, . M. I., Kokelu, . A. N., Oladosu, . O. A., Mukharjee, . T. & Akande, . A. O. (2026) Comparative Genomic Analysis of Cancer-Associated Mutations across Different Tumour Types: Insights Into Shared and Unique Therapeutic Targets. Journal of Cancer Research and Reviews, 3 (1), 20-37. doi:10.5455/JCRR.2026.v3.i1.2